The main objective of BOW is to create hybrid magnetic nanoparticles with a membrane surface made from an extracellular vesicle

This creation will shape the information contained inside the nanodevice or nanomaterial. If successful, such a non-incremental technology will promote the progress of implantable nanodevices and nanomaterials towards sustainable production and clinical translation, contributing to strengthen and keep in the lead position European biotechnology and impacting life quality for people.

Objectives

Produce high-grade small EVs with biomimetic and organotropic functions
Synthesis and functionalization of MBDs
Engineering a microfluidic device for streamlined fabrication of EV membrane coated MBDs (evMBDs)
Evaluation of evMBD biological performances and nanotoxiciy in-vitro, ex-vivo and in-vivo.

Where

BOW brings together a strong and complementary consortium, including 11 partners from 7 European countries (Italy, Spain, Germany, Ireland, Switzerland, Estonia, and Czechia)

Consorzio interuniversitario per lo sviluppo dei Sistemi a Grande Interfase

CSGI (Center for Colloid and Surface Science) is a public research institution which gathers several Italian academic groups with established research track record in Soft Matter and Surface Science

Consiglio Nazionale Delle Ricerche

CNR is the largest public research institution in Italy, performing multidisciplinary activities. Founded as legal entity on 18 November 1923

Universidad de Santiago de Compostela

The Nanotechnology and Magnetism Group-NANOMAG, University of Santiago de Compostela, is a leading group in magnetism, design, development and biofunctionalization of nanomaterials related to the subject of this project: multifunctional superparamagnetic (SPM) nanomaterials, capable of being triggered by remote magnetic control devices.

Max-Planck-Institut für Polymerforschung

MPIP ranks among the top research centres in the field of polymer science worldwide. In 2019 a total of 520 people were working at the MPIP. The workforce was composed of 100 scientists and directors, about 50 postdocs, 190 doctoral students, 40 diploma students and auxiliary staff, and 130 technical and administrative staff.

Zabala Innovation

ZABALA is specialized in providing services to public administrations in the definition of new support innovation tools (definition of new rules related with public procurement as a relevant tool to support the innovation – CPI and PPI) and in supporting the exploitation of R&D results in regional, national, and European projects.

Helmholtz Zentrum Muenchen Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt

The Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU, German Research Center for Environmental Health) is a research institution of the Federal Republic of Germany and the Free State of Bavaria.

Institute Of Technology Sligo

ITS boasts of an excellent history in innovation and research, providing a focal point for local economic development via its Business and Innovation Centre, that hosts several start-up companies. The Institute provides an on campus stimulating and supportive environment to nurture entrepreneurship and promotes the translation of research outputs into industry-oriented products and solutions in support of the regional economic development.

Eidgenoessische Technische Hochschule Zuerich

The Federal Polytechnical School, ETH Zurich (ETHZ) is wellknown for its excellent education, ground-breaking fundamental research and for putting its new findings directly into practice. ETHZ has a demonstrated experience in bioengineering and microfluidics research. ETHZ will be responsible for in WP3, to develop a microfluidic device for streamlined transferring/grafting of the EV membrane onto the MBDs.

Hansabiomed Life Sciences Ou

HBM is a research-intensive and market-oriented company operating since 2007 in Tallinn, engaged in development of innovative tools for Life Science Research on Exosomes and other Extracellular Vesicles.

Biodevice Systems

BIODEVICE systems, based in the Czech Republic, is an independent provider of certified cell-based testing and computationally assisted assay for the international life science industry. It supplies cell-based analysis with exceptional predictive value.

Rigenerand

Rigenerand srl (RR) is a start-up company spinning out from the University of Modena & Reggio Emilia (Modena,Italy). RR is a SME representing a unique enterprise, conjugating cGMP-grade cell manufacturing for cells and gene therapies with the design and development of avant-garde biomedical devices.