Our primary choice are SPM colloidal iron oxide and iron oxide-based core-shell nanostructures able to respond under low magnetic fields suitable for cell magnetic separation devices, magnetic hyperthermia, and magnetic resonance imaging contrast agents. In addition, these SPM nanostructures will be designed with inorganic shells/matrices (silica, mesoporous silica, or carbon, etc) to facilitate release of relevant molecules, and decorated with biological agents, plasmonic NPs (Ag, Au) and fluorescent moieties (rhodamine, fluorescein, dopamine) for detection and imaging purposes. In the present project, NANOMAG group of USCs will be responsible for the design, development and bioconjugation of superparamagnetic iron oxide-based nanostructures for EV engineering.