The main objective of BOW is to create hybrid magnetic nanoparticles with a membrane surface made from an extracellular vesicle
This creation will shape the information contained inside the nanodevice or nanomaterial. If successful, such a non-incremental technology will promote the progress of implantable nanodevices and nanomaterials towards sustainable production and clinical translation, contributing to strengthen and keep in the lead position European biotechnology and impacting life quality for people.
Nanomaterials and nanodevices constitute a key technology in improving precision medicine and therapeutic approaches. BOW wants to create hybrid magnetic nanoparticles with a membrane surface made from an extracellular vesicle that will advance in those fields. This creation will shape the information contained inside the nanodevice or nanomaterial.
It will proof and set a general and viable paradigm to establish key biomimetic functions including camouflage to the immune system and organ site/tumor targeting to any synthetic nanodevice, while being disruptive as a first example of biogenic nanotechnology. Eventually this new hybrid can be a novel high-risk/high-reward paradigm to impart biological features to toxic technology devices. The natural scale of this kind medicine is as of cellular and subcellular level.
Other major objectives of the project include the production of high-grade extracellular vesicles with biomimetic and organotrophic functions; the synthesis, and functionalization of MBDs; engineering a microfluidic device for the fabrication of extracellular vesicle membrane and the control of biological performances and the nanotoxicity in-vitro, ex-vivo and in-vivo. If successful, such technology will promote the progress of implantable nanodevices and nanomaterials towards a sustainable production and contributing to strengthen and keep in the lead position of European biotechnology. Also, by impacting the life quality for people.
Million euros budget
Produce high-grade small EVs with biomimetic and organotropic functions
Synthesis and functionalization of MBDs
Engineering a microfluidic device for streamlined fabrication of EV membrane coated MBDs (evMBDs)
Evaluation of evMBD biological performances and nanotoxiciy in-vitro, ex-vivo and in-vivo.
VES4US goal is to develop a radically new platform for the eddicient profuction and functionalisatioon of EVs.
evFOUNDRY targets the unmet knowledge and technology able to streamline production of therapeutic EVs from sustainable sources, drawing the baseline for future EV bioprocessing, which is necessary for effective EV medical translation and opens to new biogenic nanotechnology.
In this project they address main respiratory toxicity pathways for representative set of nanomaterials, identify the mechanistic key events of the pathways, and relate them to interactions at bionano interface via careful post-uptake nanoparticle characterisation and molecular modelling.
MADIA developed a versatile and cost-effective in-vitro tool for early diagnosis of Alzheimer’s and Parkinson’s diseases. Alzheimer’s and Parkinson’s diseases, the two most common neurodegenerative disorder worldwide, are debilitating and largely untreatable conditions that are strongly linked with age.