The highly anticipated ISEV Annual Meeting, the premier scientific conference in the field of extracellular vesicles (EVs), is set to take place from May 17 to May 21, 2023 in Seattle. Gathering renowned researchers and scientists from around the world, this event promises to deliver groundbreaking insights and cutting-edge technology in the field.
With over 1,200 attendees expected, the ISEV Annual Meeting has become a prominent platform for sharing the latest advancements in EV research. Attendees will have the opportunity to participate in informative sessions and explore state-of-the-art technologies showcased on the exhibits floor.
In the conference our researcher Miriam Romano will be a presenting a poster titled “Does EV Biomolecular Corona Impact Surface Engineering?” The research aims to shed light on a recently reported phenomenon where EVs immersed in biofluids adsorb proteins on their surface, forming a Biomolecular Corona (BC). While the role and composition of BC in natural biofluids are being investigated, its formation and potential impact on EV surface engineering through biomolecules remain unexplored. Miriam’s study focuses on Red Blood Cell (RBC)-derived EVs engineered with the monoclonal antibody Cetuximab (CTX), the target ligand of EGFR. By introducing this novel problem and presenting initial findings, the research aims to advance our understanding of BC’s role in EV surface engineering.
Sabrina Picciotto will deliver an oral presentation titled “Extracellular Vesicles Derived from Microalgae: Bio-compatibility, -Distribution, and -Activity.” The research centers around nanoalgosomes, EVs derived from microalgae that have shown potential as nanocarriers for precision medicine. Previous studies have explored their bio-chemical and physical characteristics based on MISEV2018 guidelines. Notably, nanoalgosomes have exhibited non-cytotoxic properties and demonstrated the ability to bypass cell membranes in various cell lines and C. elegans cells. At ISEV 2023, Sabrina will present findings on the in vitro endogenous bioactivity of nanoalgosomes, as well as their biocompatibility and bio-distribution in a mouse model.
In addition to her presentation, Sabrina has also been awarded the prestigious ISEV scholarship. The scholarship, designed to support researchers pursuing studies in extracellular vesicles, will enable Sabrina to attend ISEV2023 and contribute further to the field. More information on the scholarship can be found at talley.eventsair.com/isev2023/scholarships.
Karl Normak will also be participating. In the Saturday session on innovative technologies, he will be delivering an oral presentation. The abstract of his presentation focuses on the characterization of extracellular vesicles (EVs), which are membrane-enclosed biological nanoparticles with immense potential as diagnostic markers and carriers for therapeutics. Due to their complex structure and composition, characterizing EVs presents significant challenges that require the integration of orthogonal analytical techniques. His presentation will demonstrate the effectiveness of combining liquid chromatography with multi-angle light scattering (MALS) and fluorescence detection for the multi-parametric characterization of EV samples. This approach allows for the determination of particle concentration, average particle diameter, protein-to-particle ratio, presence of EV surface markers and lipids, EV shape, and sample purity. Notably, this method offers advantages such as minimal sample requirement (approximately 107 EVs), limited sample handling, rapid data analysis within minutes, full automation, and applicability to both crude and purified samples.
The ISEV Annual Meeting promises to be an exciting and enlightening event, fostering collaboration and innovation in the rapidly evolving field of extracellular vesicles. Researchers, scientists, and attendees alike eagerly anticipate the breakthroughs and advancements that will emerge from this prestigious gathering.
